Toward disposable photonic biosensors for early lung cancer detection

In this work, we measured human Serum Albumin proteins, which are vital proteins in the human body, using a photonic microring resonator (MRR) system. This system was combined with a novel readout unit utilizing an inexpensive dithering laser and a photodetector. Additionally, we developed a custom microfluidic delivery system. The MRRs were realized using silicon nitride-loaded amorphous silicon carbide waveguides. We assessed the thermal response of the MRR, which was calculated to be 16 pm/°C. During the Albumin measurements, the lowest concentration of 0.105 mg/mL exhibited a shift of 1.45·10⁻² nm after 15 minutes. In the next phase, these sensors will be used for detecting lung cancer autologous antibodies.