Miniaturized Head-Mount Doppler Optical Coherence Tomography Scope for Freely Moving Mouse

Optical brain imaging has several advantages over other imaging techniques and was used to visualize both the structural and functional aspects of the brain, providing a more complete picture of brain activity. One of the promising techniques is optical coherence tomography (OCT), which uses low-coherence interferometry to obtain three-dimensional depth-resolved imaging of structures. In this research, we present a miniaturized head-mount Doppler OCT system tailored for high-resolution brain imaging in freely moving mice, providing an advanced non-invasive imaging tool in neuroscience research. With a maximum 4×4mm field of view, 7.4μm axial resolution, the system offers reliable imaging capabilities. Its compact design and comprehensive imaging capabilities make it well-suited for studying various brain regions and dynamic processes, contributing significantly to our understanding of brain function and pathology.