Retinal morphological and vascular images of marmoset (Callithrix jacchus) using wide-field spectral-domain OCT

Non-human primates have been considered an excellent model for gene-related retinal disease research. Marmosets, one of the non-human primates with visual optics like humans, have the advantage of transgenic modification with rapid generation changes. It is well known that optical coherence tomography (OCT) and OCT-angiography (OCTA) are powerful tools for diagnosing and managing retina diseases. However, commercialized OCT designed for humans was unsuitable for 3-D retinal morphological and vascular (angiography) images of a marmoset. In this study, we developed a real-time wide field of view spectral-domain OCT (SD-OCT) to obtain retinal cross-sectional and angiographic images of the marmoset. We could obtain high-resolution cross-section images of both the optic nerve and fovea of the marmoset in a single image and visualize the retinal blood vessel networks clearly. In addition, our SD-OCT could obtain the retinal image of not only animals (mouse and marmoset) but also humans as a single system.