Optophysiology using dynamic full-field optical coherence tomography

This work presents the adaptation of an in-vivo signal processing technique for in-vitro applications, allowing for non-invasive assessment of photoreceptor function in retinal samples using dynamic full-field optical coherence tomography (D-FF-OCT). By analyzing the response of macaque retinal explants to visible light stimulation, we demonstrate the effectiveness of this method in evaluating cellular behavior and photoreceptor function. This innovative approach holds significant potential for disease modeling and therapy testing on retinal samples, including applications in stem cell-derived organoids and patient-derived cells. Our findings show feasability of optophysiology using D-FF-OCT.