Intracellular activity-type and parameter estimation from dynamic optical coherence tomography signals

Dynamic optical coherence tomography (DOCT) can contrast intracellular motilities, but it is hard to quantitatively measure the intracellular motility from DOCT. We propose a method to estimate the intracellular activity type and its motion parameters from DOCT. We used two DOCT algorithms with OCT images with two resolutions, where all of them are generated from the same OCT dataset. The method was applied to tumor spheroids and determined the motion type and the speed of intracellular scatterers.