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25 - 30 January 2025
San Francisco, California, US
Conference 13305 > Paper 13305-25
Paper 13305-25

In-vivo collagen orientation assessment to predict progression in idiopathic pulmonary fibrosis using polarization sensitive endobronchial optical coherence tomography

28 January 2025 • 9:00 AM - 9:15 AM PST | Moscone South, Room 203 (Level 2)

Abstract

Idiopathic pulmonary fibrosis (IPF), characterized by excessive collagen deposition in the lung, has widely variable prognosis that is difficult to predict but is important in therapeutic decision-making for individual patients. Polarization-sensitive endobronchial optical coherence tomography (PS-EB-OCT) is a bronchoscope-compatible volumetric imaging modality that detects in-vivo microscopic disease features of IPF and simultaneously visualizes collagen orientation. Here, we demonstrate the utility of in-vivo collagen orientation assessment using PS-EB-OCT as a novel, patient-specific optical biomarker to predict prognosis in subjects with early IPF.

Presenter

Massachusetts General Hospital (United States)
Jaeyul Lee is a post-doctoral research fellow in the lab of Dr. Lida Hariri in the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital, Harvard Medical School. He received his Ph.D. degree in School of Electronic and Electrical Engineering from Kyungpook National University, Daegu, South Korea, in 2021 and then completed a 1-year postdoctoral research fellowship in the Department of Bioengineering at the University of California, Los Angeles. His research interests are in the development of functional optical imaging techniques, including optical coherence tomography, photoacoustic microscopy and their biomedical pulmonary applications.
Application tracks: Translational Research
Presenter/Author
Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)
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Colleen M. Keyes
Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)
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Michael Lanuti
Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)
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Massachusetts General Hospital (United States)