Paper 13354-7
Paper 13354-7
Exploring mechanics of protein printing (Invited Paper)
28 January 2025 • 2:10 PM - 2:35 PM PST | Moscone South, Room 201 (Level 2)
Abstract
Protein-based 3D nano-scaffolds are crucial for modern tissue engineering, offering biocompatible and biodegradable support for tissue development. Multiphoton Lithography (MPL) allows rapid prototyping of these scaffolds with sub-1µm features and tuneable mechanical properties. Unlike synthetic polymers, protein-based materials possess inherent biofunctionality, although the impact of photodamage of the proteins during MPL is under-investigated. In this contribution, we used methacrylated proteins mixed with a vitamin-based photoinitiator to explore the impact of methacrylation, residual absorption, and reactive oxygen species on the polymerization threshold and protein functionality after printing. The research is vital for developing protein-based materials for biomedical applications.
Presenter
Jaroslaw Jacak
FH Oberösterreich (Austria)
Prof. Jaroslaw Jacak received his Master's (2004) and PhD (2009) degrees in technical physics at the Institute of Biophysics at Johannes Kepler University, Linz, Austria, under the supervision of Prof. Gerhard Schütz.
He worked as PostDoc first at Medical University Vienna and then at Johannes Kepler University Linz and University of Applied Science Upper Austria. Since 2014, he has been a professor Prof. in the Medical Engineering Department. Faculty of Applied Health and Social Sciences, Upper Austria University of Applied Sciences where he organized his own research group. Since 2023, he has also led a Department of Nanoparticle-based Therapies at Ludwig Boltzmann Institute for Traumatology in Vienna. The research interests include photochemistry, 3D optical lithography and super-resolution microscopy in biophysics applications.