Dynamic OCT simulator based on mathematical models of intratissue dynamics, image formation, and measurement noise

Dynamic optical coherence tomography (DOCT) is a label-free modality that images intracellular and intratissue motilities of tissue. This study introduces a DOCT simulator using mathematical models to represent seven types of intratissue dynamics, generating dynamic OCT speckle patterns by considering two image formation models and accounting for measurement noise. Our simulation results show that logarithmic intensity variance (LIV), OCT correlation decay speed (OCDS) and amplitude power spectrum (APS) are sensitive to scatterer velocity. The fidelity of DOCT signals is preserved when the signal-to-noise ratio exceeds 30dB, but they lose responsiveness when it drops below 10dB.