My adventure into the area of molecular imaging was sparked by various influences: my deep-seated curiosity about optical nanoscopy fueled my fascination; deciphering the complex workings of biological systems further ignited my interest; and pioneering accomplishments in molecular imaging served as a guiding light for my own research endeavors.

In my current role, my primary responsibilities revolve around developing and applying cutting-edge multimodal optical-imaging technologies including stimulated Raman scattering microscopy, multiphoton fluorescence microscopy, and second harmonic generation microscopy. I integrated these modalities into a single multimodal platform to study metabolic dynamics in aging and diseases.

One of my greatest accomplishments to date is the development of a series of metabolic-nanoscopy technologies that allow the visualization of metabolic activity of multiple new and old molecules with unprecedented molecular specificity at subcellular resolution, enabling us to observe complex molecular structures and organelles in cells and tissues with high spatial and temporal resolution.

The biggest challenges have been navigating the landscape of interdisciplinary research and overcoming technical hurdles associated with developing novel optical-imaging technologies. To overcome these challenges, I cultivated a collaborative mindset, leveraging the expertise of colleagues from diverse fields.

For young girls or women considering a career in STEM, I advise them to cultivate their curiosity, passion, and perseverance. Do not be afraid to pursue your interests; seek out role models, mentors, and allies; and never underestimate the value of your unique perspective and contributions to the field.

The impact I hope to have is twofold: firstly, to advance our understanding of complex biological processes such as aging and related diseases, and, secondly, to inspire and empower the next generation of scientists, particularly women.

Ultimately, I believe that making a difference in the world begins with a commitment to curiosity, collaboration, and compassion. By pushing the boundaries of scientific knowledge and fostering inclusivity and diversity in STEM fields, we can create a more equitable and sustainable future for generations to come.

Lingyan Shi
Associate Professor, Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego
Born in China / Resides in United States
Educational Background: PhD in Biomedical Engineering, City College of New York, United
States